Chemical synthesis of all-trans retinoyl beta-glucuronide.
All-trans retinoyl fluoride reacts with the 3,6-lactone of glucuronic acid in slightly alkaline solution to give the lactone of retinoyl beta-glucuronide, along with other retinoyl glucurono-lactones, in about 60% yield.Hydrolysis of the lactone with very dilute alkali gives CONDITIONER COOL PEPPERMINT the free acid, retinoyl beta-glucuronide, in a